Acute Social Defeat Stress Increases Sleep in Mice
نویسندگان
چکیده
منابع مشابه
Effects of Social Defeat Stress on Sleep in Mice
Stress plays a key role in the development of psychiatric disorders and has a negative impact on sleep integrity. In mice, chronic social defeat stress (CSDS) is an ethologically valid model of stress-related disorders but little is known about its effects on sleep regulation. Here, we investigated the immediate and long-term effects of 10 consecutive days of social defeat (SD) on vigilance sta...
متن کاملEthological Evaluation of the Effects of Social Defeat Stress in Mice: Beyond the Social Interaction Ratio
In rodents, repeated exposure to unavoidable aggression followed by sustained sensory treat can lead to prolonged social aversion. The chronic social defeat stress model explores that phenomenon and it has been used as an animal model for human depression. However, some authors have questioned whether confounding effects may arise as the model also boosts anxiety-related behaviors. Despite its ...
متن کاملDelta Opioid Receptor Signaling Promotes Resilience to Stress Under the Repeated Social Defeat Paradigm in Mice
Axe Neurosciences, Centre de Recherche du CHU de Québec—Université Laval, Québec, QC, Canada, Centre de Recherche du CHU de Sherbrooke and Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, Département de Pharmacologie-Physiologie, Université de Sherbrooke, Sherbrooke, QC, Canada, Quebec Pain Research Network, Sherbrooke, QC, Canada, Integrated Program in...
متن کاملHypothalamic orexin prevents hepatic insulin resistance induced by social defeat stress in mice.
Depression is associated with insulin resistance and type 2 diabetes, although the molecular mechanism behind the pathological link remains unclear. Orexin, a hypothalamic neuropeptide regulating energy and glucose homeostasis, has been implicated in the endogenous antidepressant mechanism. To clarify whether orexin is involved in the coordination between mental and metabolic functions, we inve...
متن کاملFelbamate reduces hormone release and locomotor hypoactivity induced by repeated stress of social defeat in mice.
Glutamatergic neurotransmission plays a role in stress hormone release and the development of mood diseases. The aim of these studies was to verify the hypothesis that repeated treatment with felbamate, an antiepileptic drug modulating glutamatergic neurotransmission, affects hormone release in response to chronic stress. A mouse model of repeated social defeat (nonaggressive male mouse repeate...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Neuroscience
سال: 2019
ISSN: 1662-453X
DOI: 10.3389/fnins.2019.00322